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When blood glucose is high, over time it causes blood vessels to become inflamed. High blood glucose accelerates the buildup of a waxy, fatty substance called plaque inside the vessels. Inflammation and plaque narrow and can block the blood vessels that supply blood to the heart, eyes, kidneys, and nerves. This causes damage to the body in a slow, gradual process
"It's important to note that nothing happens quickly with diabetes," says Jackson.
Genetics do play a role in the type and severity of complications you might experience. But researchers are still piecing together the exact clues to explain the genetic links.
The Good News: "There's also a lot we can do nowadays to stop the progression of complications once they set in," Jackson says. Things you can directly affect, such as healthful eating, activity, and blood glucose and blood pressure control, make a big difference.

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